In vitro diagnostic (IVD) ELISA kits
Firalis provides colorimetric sandwich ELISA kits CE-marked (IVD) for use in human samples. Our validation process is compliant with the most stringent requirements of the ISO 17025 norm (GLPC compliant) ensuring our customers to use the most adapted and reliable tool for their analysis.
For in vitro diagnosis of risk of heart failure by quantification of MMP-9 protein in human EDTA plasma
Matrix Metelloproteinase-9 (MMP-9) is part of the matrix metalloproteinase family presenting a group of structurally related zinc-containing proteolytic enzymes. These enzymes play an important role in tissue remodeling of extracellular matrix. MMP-9 is a 92 kDa protein with a sequence length of 707 amino acids that is produced by epithelial cells and is stored in the secretory granules of neutrophils and eosinophils. It has been shown to mediate vascular leakage and to initiate the migration of inflammatory cells inducing wound repair.
For in vitro diagnosis of heart failure by quantification of NGAL protein in human EDTA plasma
NGAL, a protein belonging to lipocalin family, plays an important role in vascular remodelling and plaque instability of atherosclerosis1,2. NGAL is found to be upregulated in cardiomyocytes in failing myocardium3. Plasma NGAL is a significant predictor of mortality and cardiovascular disease in community-dwelling older adults, independent of traditional risk factors and kidney function, and adds incremental value to NT-proBNP and CRP4.
IFU FiQuantiGal NGAL CE-IVD ELISA FRNGAL/MMP-9 complex ELISA
For in vitro quantification of NGAL/MMP-9 complex protein in human plasma
Neutrophil gelatinase-associated lipocalin (NGAL)-Matrix metallopeptidase 9 (MMP-9) complex, is complex of two independent protein (NGAL) and MMP-9. By complexing MMP-9, NGAL stabilise the MMP-9 et protect it from the proteolytic degradation and consequently increasing the enzymatic activity of MMP-9. Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a 24 kDa secreted glycoprotein and can promote MMP-9 activity in part by protecting MMP-9 from autolysis 1,2. NGAL can promote MMP-9 activity by forming a complex with the protease (NGAL/MMP-9).