Firalis provides colorimetric sandwich ELISA kits developed and validated for biomarker measurement in blood-derived matrices samples. Our validation process is compliant with the most stringent requirements of the ISO 17025 norm (GLPC compliant) ensuring our customers to use the most adapted and reliable tool for their analysis.
- Calponin-1 (CNN-1)
Calponin-1 (or CNN-1) is the smooth muscle counter-part protein of the Troponin, found in the myocardium. Three isoforms have been described, the basic Calponin isoform remains highly specific to smooth muscle.
Through binding to Actin, Calmodulin, Troponin C and Tropomyosin, it is postulated that Calponin-1 regulates the contractility of the smooth muscle.
Due to the analogy with Troponin proteins (myocardial necrosis marker) and the high tissue specificity, CNN-1 has been recently explored as a circulating marker of arterial damage.
Brochure PDF: Firalis Brochure ELISA kit CNN1
Clusterin is a glycoprotein, also known as Apolipoprotein J, which is often associated with the clearance of cellular debris, control of cell proliferation and apoptosis. It is expressed in most mammalian tissues and is detected in plasma, milk, urine, cerebrospinal fluid and semen.
Many new publications showed that serum Clusterin level increases significantly in patients with developing coronary heart disease, or myocardial infarction.
Clusterin is an interesting circulating biomarker to study the physiopathology of the Heart Failure.
Brochure PDF: Firalis Brochure ELISA kit Clusterin
Caldesmon, predominantly expressed in smooth muscle thin filament, is considered to be potential modulator of smooth muscle contraction.
Migration of vascular smooth muscle cells (SMCs) from the media to the intima layers constitutes a critical step in the development of proliferative vascular diseases such as atherosclerosis and in response to vascular injuries like angioplasty and organ transplantation.
Caldesmon have the potential to serve as a sensitive and specific signal of smooth muscle necrosis both in DIVI and in human vascular disease. Recent research also showed the implication of this protein in other diseases such as endometriosis and cancer.
Brochure PDF: Firalis Brochure ELISA kit Caldesmon
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